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Investigating mirror system (MS) activity in adults with ASD when inferring others' intentions using both TMS and EEG

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journal contribution
posted on 01.07.2018, 00:00 authored by Eleanor J Cole, Nick E Barraclough, Peter EnticottPeter Enticott
ASD is associated with mentalizing deficits that may correspond with atypical mirror system (MS) activation. We investigated MS activity in adults with and without ASD when inferring others' intentions using TMS-induced motor evoked potentials (MEPs) and mu suppression measured by EEG. Autistic traits were measured for all participants. Our EEG data show, high levels of autistic traits predicted reduced right mu (8-10 Hz) suppression when mentalizing. Higher left mu (8-10 Hz) suppression was associated with superior mentalizing performances. Eye-tracking and TMS data showed no differences associated with autistic traits. Our data suggest ASD is associated with reduced right MS activity when mentalizing, TMS-induced MEPs and mu suppression measure different aspects of MS functioning and the MS is directly involved in inferring intentions.

History

Journal

Journal of autism and developmental disorders

Volume

48

Issue

7

Pagination

2350 - 2367

Publisher

Springer

Location

New York, N.Y.

ISSN

0162-3257

eISSN

1573-3432

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2018, The Authors