enticott-investigatingmirror-2018.pdf (1.1 MB)
Investigating mirror system (MS) activity in adults with ASD when inferring others' intentions using both TMS and EEG
journal contributionposted on 2018-07-01, 00:00 authored by Eleanor J Cole, Nick E Barraclough, Peter EnticottPeter Enticott
ASD is associated with mentalizing deficits that may correspond with atypical mirror system (MS) activation. We investigated MS activity in adults with and without ASD when inferring others' intentions using TMS-induced motor evoked potentials (MEPs) and mu suppression measured by EEG. Autistic traits were measured for all participants. Our EEG data show, high levels of autistic traits predicted reduced right mu (8-10 Hz) suppression when mentalizing. Higher left mu (8-10 Hz) suppression was associated with superior mentalizing performances. Eye-tracking and TMS data showed no differences associated with autistic traits. Our data suggest ASD is associated with reduced right MS activity when mentalizing, TMS-induced MEPs and mu suppression measure different aspects of MS functioning and the MS is directly involved in inferring intentions.
JournalJournal of autism and developmental disorders
Pagination2350 - 2367
LocationNew York, N.Y.
Link to full text
Publication classificationC1 Refereed article in a scholarly journal
Copyright notice2018, The Authors
Autism spectrum disorder (ASD)Electroencephalography (EEG)IntentionsMentalizingMirror system (MS)Transcranial magnetic stimulation (TMS)Social SciencesPsychology, DevelopmentalPsychologyAUTISM SPECTRUM DISORDERSTRANSCRANIAL MAGNETIC STIMULATIONHIGH-FUNCTIONING AUTISMNEURON SYSTEMASPERGER-SYNDROMEMU-SUPPRESSIONSINGLE-PULSEQUOTIENT AQCORTICAL UNDERCONNECTIVITYCORTICOSPINAL EXCITABILITYEducation