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Investigating neurophysiological markers of impaired cognition in schizophrenia
journal contribution
posted on 2021-07-01, 00:00 authored by K E Hoy, H Coyle, K Gainsford, Aron HillAron Hill, N W Bailey, P B FitzgeraldCognitive impairment is highly prevalent in schizophrenia and treatment options are severely limited. A greater understanding of the pathophysiology of impaired cognition would have broad implications, including for the development of effective treatments. In the current study we used a multimodal approach to identify neurophysiological markers of cognitive impairment in schizophrenia. Fifty-seven participants (30 schizophrenia, 27 controls) underwent neurobiological assessment (electroencephalography [EEG] and Transcranial Magnetic Stimulation combined with EEG [TMS-EEG]) and assessment of cognitive functioning using an n-back task and the MATRICS Consensus Cognitive Battery. Neurobiological outcome measures included oscillatory power during a 2-back task, TMS-related oscillations and TMS-evoked potentials (TEPs). Cognitive outcome measures were d prime and accurate reaction time on the 2-back and MATRICS domain scores. Compared to healthy controls, participants with schizophrenia showed significantly reduced theta oscillations in response to TMS, and trend level decreases in task-related theta and cortical reactivity (i.e. reduced N100 and N40 TEPs). Participants with schizophrenia also showed significantly impaired cognitive performance across all measures. Correlational analysis identified significant associations between cortical reactivity and TMS-related oscillations in both groups; and trend level associations between task-related oscillations and impaired cognition in schizophrenia. The current study provides experimental support for possible neurophysiological markers of cognitive impairment in schizophrenia. The potential implications of these findings, including for treatment development, are discussed.
History
Journal
Schizophrenia ResearchVolume
233Pagination
34 - 43Publisher DOI
ISSN
0920-9964eISSN
1573-2509Publication classification
C1 Refereed article in a scholarly journalUsage metrics
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No categories selectedKeywords
Science & TechnologyLife Sciences & BiomedicinePsychiatryNon-invasive brain stimulationOscillationsCortical reactivityCognitive impairmentExperimental therapeuticsDIRECT-CURRENT STIMULATIONDORSOLATERAL PREFRONTAL CORTEXWORKING-MEMORYGAMMA-OSCILLATIONSBRAIN-STIMULATIONTMS-EEGINHIBITIONMECHANISMSSYNCHRONYDYSFUNCTIONexperimental therapuetics
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