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Investigating the changes in heart rate asymmetry (HRA) with perturbation of parasympathetic nervous system
journal contribution
posted on 2012-12-01, 00:00 authored by Chandan KarmakarChandan Karmakar, A Khandoker, M PalaniswamiThe heart rate asymmetry (HRA) is a disproportionate distribution of heart rate signal. The current study was designed to assess the changes in HRA in experimental conditions using Poincaré plot during parasympathetic blockade (atropine infusion) and parasympathetic enhancement (scopolamine administration). After atropine infusion, the heart rate variability in 5 out of 8 subjects was found asymmetric. In contrast, all 8 subjects were found to be asymmetric during scopolamine administration. The physiological relevance of HRA was demonstrated by showing correlation with standard frequency domain parameters during all phases of the experiment. The deviation of asymmetry index (GI ( p )) from symmetric range was further analyzed, which was maximum during scopolamine administration and minimum during atropine infusion. These findings suggest that parasympathetic block reduces the prevalence of HRA, and has significant correlation of GI ( p ) with frequency domain features of HRV analysis.
History
Journal
Australasian physical and engineering sciences in medicineVolume
35Issue
4Pagination
465 - 474Publisher
SpringerLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0158-9938Language
engPublication classification
C1.1 Refereed article in a scholarly journal; C Journal articleCopyright notice
2012, Australasian College of Physical Scientists and Engineers in MedicineUsage metrics
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No categories selectedKeywords
Heart rate asymmetry (HRA)Heart rate variability (HRV)Poincare´ plotParasympathetic activityScience & TechnologyTechnologyEngineering, BiomedicalEngineeringPoincare plotCARDIAC AUTONOMIC FUNCTIONRATE-VARIABILITYLONG-TERMESSENTIAL-HYPERTENSIONSYMPATHOVAGAL BALANCEPERIOD VARIABILITYSPECTRAL-ANALYSISRATE DYNAMICSVAGAL
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