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Investigation of fucoidan–oleic acid conjugate for delivery of curcumin and paclitaxel

Version 2 2024-06-06, 08:55
Version 1 2016-07-06, 13:29
journal contribution
posted on 2024-06-06, 08:55 authored by UT Phan, KT Nguyen, TV Vo, Wei DuanWei Duan, PHL Tran, TTD Tran
Nanoparticles for a specific delivery are likely to be designed for cancer therapeutic effectiveness and improvement. In this study, a fucoidan-oleic acid conjugate was prepared and investigated in terms of loading capacity for poorly water-soluble anti-cancer drugs to maximize effectiveness of the treatment. Fucoidan was used as a hydrophilic portion of an amphiphilic structure for improving cancer therapeutic effects. Paclitaxel and curcumin were chosen as other model drugs loaded in the conjugates. The results showed that self-assembled nanoparticles with different sizes and morphologies could be prepared with two different concentrations of oleic acid as hydrophobic portion. Moreover, loading efficiency and release patterns of these drugs were mainly dependent on the hydrophobic interaction between drugs and oleic acid. It was also revealed that fucoidan and curcumin were released higher at pH 4.5 than at the physiological condition (pH 7.4), thus, facilitating the delivery and maximizing effects of the anticancer agents on cancer cells. On the contrary, paclitaxel from fucoidan nanoparticles was released faster at pH 7.4. The exploration of fucoidan–oleic acid conjugate could be considered as promising nanomedicines for cancer therapeutics.

History

Journal

Anti-Cancer Agents in Medicinal Chemistry

Volume

16

Pagination

1281-1287

Location

Netherlands

ISSN

1871-5206

eISSN

1875-5992

Language

English

Publication classification

C Journal article, C1 Refereed article in a scholarly journal

Copyright notice

2016, Bentham Science Publishers

Issue

10

Publisher

BENTHAM SCIENCE PUBL LTD