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Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis

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Version 2 2024-06-04, 15:42
Version 1 2018-08-24, 14:25
journal contribution
posted on 2024-06-04, 15:42 authored by Haloom Rafehi, Katherine Ververis, Aneta Balcerczyk, Mark ZiemannMark Ziemann, Jenny Ooi, Sean Hu, Faith AA Kwa, Shanon J Loveridge, George T Georgiadis, Assam El-Osta, Tom C Karagiannis
The accumulating evidence of the beneficial effects of cinnamon (Cinnamomum burmanni) in type-2 diabetes, a chronic age-associated disease, has prompted the commercialisation of various supplemental forms of the spice. One such supplement, Cinnulin PF(®), represents the water soluble fraction containing relatively high levels of the double-linked procyanidin type-A polymers of flavanoids. The overall aim of this study was to utilize genome-wide mRNA-Seq analysis to characterise the changes in gene expression caused by Cinnulin PF in immortalised human keratinocytes and microvascular endothelial cells, which are relevant with respect to diabetic complications. In summary, our findings provide insights into the mechanisms of action of Cinnulin PF in diabetes and diabetic complications. More generally, we identify relevant candidate genes which could provide the basis for further investigation.

History

Journal

Pathobiology of aging and age-related diseases

Volume

2

Pagination

1-14

Location

Abingdon, Eng.

Open access

  • Yes

ISSN

2001-0001

eISSN

2001-0001

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2012, Haloom Rafehi et al.

Publisher

Taylor & Francis

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