Invited editorial presents an accurate summary of the results of two randomised placebo-controlled trials of vertebroplasty
journal contribution
posted on 2010-03-15, 00:00 authored by R Buchbinder, Richard Osborne, D KallmesOur recent editorial in the Journal presents an accurate summary of our two randomised trials of vertebroplasty, which found no benefit of vertebroplasty over placebo.
Participants in both trials are representative of patients seen in clinical practice and who would qualify for government-subsidised funding of vertebroplasty in Australia.
Clinical experience and previous published literature are likely to have overestimated the treatment benefit of vertebroplasty for many reasons.
This is why randomised placebo-controlled trials are required to determine the efficacy of treatment interventions, particularly when the condition being treated is self-limiting and the primary end point is improvement of symptoms.
Based on the best evidence currently available, the routine use of vertebroplasty outside of the research setting for painful osteoporotic vertebral fractures appears unjustified.
Participants in both trials are representative of patients seen in clinical practice and who would qualify for government-subsidised funding of vertebroplasty in Australia.
Clinical experience and previous published literature are likely to have overestimated the treatment benefit of vertebroplasty for many reasons.
This is why randomised placebo-controlled trials are required to determine the efficacy of treatment interventions, particularly when the condition being treated is self-limiting and the primary end point is improvement of symptoms.
Based on the best evidence currently available, the routine use of vertebroplasty outside of the research setting for painful osteoporotic vertebral fractures appears unjustified.
History
Journal
Medical journal of AustraliaVolume
192Issue
6Pagination
338 - 341Publisher
Australasian Medical Publishing Company Pty LtdLocation
Strawberry Hills, N.S.W.ISSN
0025-729XeISSN
1326-5377Language
engPublication classification
C2 Other contribution to refereed journalCopyright notice
2010, Australasian Medical Publishing CompanyUsage metrics
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