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Iron-catalyzed acylative dealkylation of N-alkylsulfoximines

Version 2 2024-06-17, 22:28
Version 1 2017-04-06, 12:11
journal contribution
posted on 2024-06-17, 22:28 authored by P Lamers, DL Priebbenow, C Bolm
As a result of our recent investigations into the N-functionalization of sulfoximines, an iron-catalyzed dealkylative acylation of N-alkylsulfoximines has been developed. This process involves a Polonovski-type dealkylation of an N-alkylated sulfoximine to afford a reactive intermediate that is trapped in the presence of a suitable aldehyde or anhydride to afford N-acyl- and N-aroylsulfoximine derivatives in one pot. Subsequent cleavage of the acyl or aroyl group under acidic conditions generates a synthetically valuable NH-sulfoximine.

History

Journal

European journal of organic chemistry

Volume

2015

Pagination

5594-5602

Location

Weinheim, Germany

ISSN

1434-193X

eISSN

1099-0690

Language

eng

Publication classification

C Journal article, C1.1 Refereed article in a scholarly journal

Copyright notice

2015, Wiley-VCH

Issue

25

Publisher

Wiley-VCH