Iron-catalyzed acylative dealkylation of N-alkylsulfoximines
Version 2 2024-06-17, 22:28Version 2 2024-06-17, 22:28
Version 1 2017-04-06, 12:11Version 1 2017-04-06, 12:11
journal contribution
posted on 2024-06-17, 22:28authored byP Lamers, DL Priebbenow, C Bolm
As a result of our recent investigations into the N-functionalization of sulfoximines, an iron-catalyzed dealkylative acylation of N-alkylsulfoximines has been developed. This process involves a Polonovski-type dealkylation of an N-alkylated sulfoximine to afford a reactive intermediate that is trapped in the presence of a suitable aldehyde or anhydride to afford N-acyl- and N-aroylsulfoximine derivatives in one pot. Subsequent cleavage of the acyl or aroyl group under acidic conditions generates a synthetically valuable NH-sulfoximine.