File(s) under permanent embargo
Is Viral Vector Gene Delivery More Effective Using Biomaterials?
journal contribution
posted on 2021-01-01, 00:00 authored by Yi Wang, Kiara F Bruggeman, Stephanie Franks, Vini Gautam, Stuart I Hodgetts, Alan R Harvey, Richard WilliamsRichard Williams, David R NisbetGene delivery has been extensively investigated for introducing foreign genetic material into cells to promote expression of therapeutic proteins or to silence relevant genes. This approach can regulate genetic or epigenetic disorders, offering an attractive alternative to pharmacological therapy or invasive protein delivery options. However, the exciting potential of viral gene therapy has yet to be fully realized, with a number of clinical trials failing to deliver optimal therapeutic outcomes. Reasons for this include difficulty in achieving localized delivery, and subsequently lower efficacy at the target site, as well as poor or inconsistent transduction efficiency. Thus, ongoing efforts are focused on improving local viral delivery and enhancing its efficiency. Recently, biomaterials have been exploited as an option for more controlled, targeted and programmable gene delivery. There is a growing body of literature demonstrating the efficacy of biomaterials and their potential advantages over other delivery strategies. This review explores current limitations of gene delivery and the progress of biomaterial‐mediated gene delivery. The combination of biomaterials and gene vectors holds the potential to surmount major challenges, including the uncontrolled release of viral vectors with random delivery duration, poorly localized viral delivery with associated off‐target effects, limited viral tropism, and immune safety concerns.
History
Journal
Advanced Healthcare MaterialsVolume
10Issue
1Pagination
2001238 - 2001238Publisher
Wiley-VCH Verlag GmbH & Co. KGaALocation
Weinheim, GermanyPublisher DOI
ISSN
2192-2640eISSN
2192-2659Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2020, Wiley-VCH GmbHUsage metrics
Categories
No categories selectedKeywords
biomaterialseffective deliverygene deliveryviral vectorsScience & TechnologyTechnologyEngineering, BiomedicalNanoscience & NanotechnologyMaterials Science, BiomaterialsEngineeringScience & Technology - Other TopicsMaterials ScienceELECTROSPUN NANOFIBROUS SCAFFOLDSLOCALIZED LENTIVIRUS DELIVERYCONTROLLED-RELEASE STRATEGIESASSEMBLING PEPTIDE HYDROGELSSPINAL-CORD-INJURYIN-VIVOADENOASSOCIATED VIRUSIMMUNE-RESPONSESONCOLYTIC ADENOVIRUSTRANSGENE EXPRESSION
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC