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Is Viral Vector Gene Delivery More Effective Using Biomaterials?

journal contribution
posted on 01.01.2021, 00:00 authored by Yi Wang, Kiara F Bruggeman, Stephanie Franks, Vini Gautam, Stuart I Hodgetts, Alan R Harvey, Richard WilliamsRichard Williams, David R Nisbet
Gene delivery has been extensively investigated for introducing foreign genetic material into cells to promote expression of therapeutic proteins or to silence relevant genes. This approach can regulate genetic or epigenetic disorders, offering an attractive alternative to pharmacological therapy or invasive protein delivery options. However, the exciting potential of viral gene therapy has yet to be fully realized, with a number of clinical trials failing to deliver optimal therapeutic outcomes. Reasons for this include difficulty in achieving localized delivery, and subsequently lower efficacy at the target site, as well as poor or inconsistent transduction efficiency. Thus, ongoing efforts are focused on improving local viral delivery and enhancing its efficiency. Recently, biomaterials have been exploited as an option for more controlled, targeted and programmable gene delivery. There is a growing body of literature demonstrating the efficacy of biomaterials and their potential advantages over other delivery strategies. This review explores current limitations of gene delivery and the progress of biomaterial‐mediated gene delivery. The combination of biomaterials and gene vectors holds the potential to surmount major challenges, including the uncontrolled release of viral vectors with random delivery duration, poorly localized viral delivery with associated off‐target effects, limited viral tropism, and immune safety concerns.

History

Journal

Advanced Healthcare Materials

Volume

10

Issue

1

Pagination

2001238 - 2001238

Publisher

Wiley-VCH Verlag GmbH & Co. KGaA

Location

Weinheim, Germany

ISSN

2192-2640

eISSN

2192-2659

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2020, Wiley-VCH GmbH