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Is fatty acid intake a predictor of arterial stiffness and blood pressure in men? Evidence from the Caerphilly Prospective Study
journal contribution
posted on 2013-11-01, 00:00 authored by Katherine LivingstoneKatherine Livingstone, D I Givens, J R Cockcroft, J E Pickering, J A LovegroveBACKGROUND AND AIMS: Arterial stiffness is an independent predictor of cardiovascular disease (CVD) events and all-cause mortality and may be differentially affected by dietary fatty acid (FA) intake. The aim of this study was to investigate the relationship between FA consumption and arterial stiffness and blood pressure in a community-based population. METHODS AND RESULTS: The Caerphilly Prospective Study recruited 2398 men, aged 45-59 years, who were followed up at 5-year intervals for a mean of 17.8-years (n 787). A semi-quantitative food frequency questionnaire estimated intakes of total, saturated, mono- and poly-unsaturated fatty acids (SFA, MUFA, PUFA). Multiple regression models investigated associations between intakes of FA at baseline with aortic pulse wave velocity (aPWV), augmentation index (AIx), systolic and diastolic blood pressure (SBP, DBP) and pulse pressure after a 17.8-year follow-up--as well as cross-sectional relationships with metabolic markers. After adjustment, higher SFA consumption at baseline was associated with higher SBP (P = 0.043) and DBP (P = 0.002) and after a 17.8-year follow-up was associated with a 0.51 m/s higher aPWV (P = 0.006). After adjustment, higher PUFA consumption at baseline was associated with lower SBP (P = 0.022) and DBP (P = 0.036) and after a 17.8-year follow-up was associated with a 0.63 m/s lower aPWV (P = 0.007). CONCLUSION: This study suggests that consumption of SFA and PUFA have opposing effects on arterial stiffness and blood pressure. Importantly, this study suggests that consumption of FA is an important risk factor for arterial stiffness and CVD.
History
Journal
Nutrition, metabolism and cardiovascular diseasesVolume
23Issue
11Pagination
1079 - 1085Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
eISSN
1590-3729Language
engPublication classification
C Journal article; C1.1 Refereed article in a scholarly journalCopyright notice
2012, Elsevier B.VUsage metrics
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Categories
Keywords
AIxArterial stiffnessBlood pressureCVDCardiovascular diseaseDBPFatty acidsHDLLDLMUFAPUFAPulse wave velocitySBPSFAaPWVaortic pulse wave velocityaugmentation indexdiastolic blood pressurehigh-density lipoproteinlow-density lipoproteinmono-unsaturated fatty acidspoly-unsaturated fatty acidssaturated fatty acidssystolic blood pressureAortaBiomarkersCardiovascular DiseasesCross-Sectional StudiesDietary FatsDisease ProgressionFatty Acids, UnsaturatedHumansHypertensionInflammation MediatorsLongitudinal StudiesLost to Follow-UpMaleMiddle AgedProspective StudiesPulse Wave AnalysisRisk FactorsVascular StiffnessWalesScience & TechnologyLife Sciences & BiomedicineCardiac & Cardiovascular SystemsEndocrinology & MetabolismNutrition & DieteticsCardiovascular System & CardiologyISCHEMIC-HEART-DISEASEPULSE-WAVE VELOCITYSATURATED FATDIETARY-FATFOLLOW-UPCARDIOVASCULAR EVENTSRISKMETAANALYSISPATTERNS