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Is there an association between early weight status and utility-based health-related quality of life in young children?

Version 2 2024-06-05, 03:58
Version 1 2018-07-20, 08:42
journal contribution
posted on 2024-06-05, 03:58 authored by EJ Tan, Victoria BrownVictoria Brown, S Petrou, M D’Souza, Marj MoodieMarj Moodie, LM Wen, LA Baur, C Rissel, AJ Hayes
PURPOSE: Few studies focus on the health-related quality of life (HRQoL) of preschool children with overweight or obesity. This is relevant for evaluation of obesity prevention trials using a quality-adjusted life year (QALY) framework. This study examined the association between weight status in the preschool years and HRQoL at age 5 years, using a preference-based instrument. METHODS: HRQoL [based on parent proxy version of the Health Utilities Index Mark 3 (HUI3)] and weight status were measured in children born in Australia between 2007 and 2009. Children's health status was scored across eight attributes of the HUI3-vision, hearing, speech, ambulation, dexterity, emotion, cognition and pain, and these were used to calculate a multi-attribute utility score. Ordinary least squares (OLS), Tobit and two-part regressions were used to model the association between weight status and multi-attribute utility. RESULTS: Of the 368 children for whom weight status and HUI3 data were available, around 40% had overweight/obesity. After adjusting for child's sex, maternal education, marital status and household income, no significant association between weight status in the preschool years and multi-attribute utility scores at 5 years was found. CONCLUSIONS: Alternative approaches for capturing the effects of weight status in the preschool years on preference-based HRQoL outcomes should be tested. The application of the QALY framework to economic evaluations of obesity-related interventions in young children should also consider longitudinal effects over the life-course. Clinical Trial Registration The Healthy Beginnings Trial was registered with the Australian Clinical Trial Registry (ACTRNO12607000168459).

History

Journal

Quality of Life Research

Volume

27

Pagination

2851-2858

Location

Netherlands

ISSN

0962-9343

eISSN

1573-2649

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2018, Springer Nature Switzerland AG

Issue

11

Publisher

SPRINGER