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Isolation and characterisation of the ylmE homologue of Thermus thermophilus

journal contribution
posted on 2001-01-01, 00:00 authored by S Spada, Y Gibert, J Pembroke, J Wall
Screening of a Thermus thermophilus genomic library led to the identification of a homologue of the ylmE gene. ylmE is highly conserved in widely divergent organisms from prokaryotes to mammals, suggesting an important, albeit currently unknown, cellular function. The 633 bp gene has a GC content of 69.2% overall and 90% in the third nucleotide position, while the gene product is predicted to be a soluble cytoplasmic protein of 23441 Da. It belongs to a family of conserved proteins of unknown function and exhibits amino acid identities ranging from 45% to 28% to the Aquifex aeolicus and Saccharomyces cerevisiae family members, respectively. We speculate that the gene product may be involved in a cellular stress response in T. thermophilus.

History

Journal

Mitochondrial DNA

Volume

11

Issue

6

Pagination

507 - 514

Publisher

Informa Healthcare

Location

London, Eng.

ISSN

1940-1736

eISSN

1940-1744

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2001, Informa Healthcare

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