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J-shaped relationship between habitual coffee consumption and 10-year (2002-2012) cardiovascular disease incidence: the ATTICA study

Version 2 2024-06-13, 12:44
Version 1 2019-01-31, 11:03
journal contribution
posted on 2024-06-13, 12:44 authored by Georgia-Maria Kouli, Demosthenes B Panagiotakos, Ekavi N Georgousopoulou, Duane D Mellor, Christina Chrysohoou, Adela Zana, Constantine Tsigos, Dimitrios Tousoulis, Christodoulos Stefanadis, Christos Pitsavos
PURPOSE: The purpose of this work was to evaluate the association between coffee consumption and 10-year cardiovascular disease (CVD) incidence in the ATTICA study, and whether this is modified by the presence or absence of metabolic syndrome (MetS) at baseline. METHODS: During 2001-2002, 3042 healthy adults (1514 men and 1528 women) living in the greater area of Athens were voluntarily recruited to the ATTICA study. In 2011-2012, the 10-year follow-up was performed in 2583 participants (15% of the participants were lost to follow-up). Coffee consumption was assessed by a validated food-frequency questionnaire at baseline (abstention, low, moderate, heavy). Incidence of fatal or non-fatal CVD event was recorded using WHO-ICD-10 criteria and MetS was defined by the National Cholesterol Education Program Adult Treatment panel III (revised) criteria. RESULTS: Overall, after controlling for potential CVD risk factors, the multivariate analysis revealed a J-shaped association between daily coffee drinking and the risk for a first CVD event in a 10-year period. Particularly, the odds ratio for low (<150 ml/day), moderate (150-250 ml/day) and heavy coffee consumption (>250 ml/day), compared to abstention, were 0.44 (95% CI 0.29-0.68), 0.49 (95% CI 0.27-0.92) and 2.48 (95% CI 1.56-1.93), respectively. This inverse association was also verified among participants without MetS at baseline, but not among participants with the MetS. CONCLUSIONS: These data support the protective effect of drinking moderate quantities of coffee (equivalent to approximately 1-2 cups daily) against CVD incidents. This protective effect was only significant for participants without MetS at baseline.

History

Journal

European journal of nutrition

Volume

57

Pagination

1677-1685

Location

Berlin, Germany

eISSN

1436-6215

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2017, Springer-Verlag Berlin Heidelberg

Issue

4

Publisher

Springer

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