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Janus Kinase 3 (JAK3): A Critical Conserved Node in Immunity Disrupted in Immune Cell Cancer and Immunodeficiency

Version 3 2024-06-18, 23:13
Version 2 2024-06-06, 12:49
Version 1 2024-04-12, 06:05
journal contribution
posted on 2024-06-18, 23:13 authored by Clifford LiongueClifford Liongue, Ratnayake Mudiyanselage Tarina RatnayakeRatnayake Mudiyanselage Tarina Ratnayake, Faiza BasheerFaiza Basheer, Alister WardAlister Ward
The Janus kinase (JAK) family is a small group of protein tyrosine kinases that represent a central component of intracellular signaling downstream from a myriad of cytokine receptors. The JAK3 family member performs a particularly important role in facilitating signal transduction for a key set of cytokine receptors that are essential for immune cell development and function. Mutations that impact JAK3 activity have been identified in a number of human diseases, including somatic gain-of-function (GOF) mutations associated with immune cell malignancies and germline loss-of-function (LOF) mutations associated with immunodeficiency. The structure, function and impacts of both GOF and LOF mutations of JAK3 are highly conserved, making animal models highly informative. This review details the biology of JAK3 and the impact of its perturbation in immune cell-related diseases, including relevant animal studies.

History

Journal

International Journal of Molecular Sciences

Volume

25

Article number

ARTN 2977

Pagination

1-13

Location

Basel, Switzerland

ISSN

1661-6596

eISSN

1422-0067

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Issue

5

Publisher

MDPI