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Ketamine and rapidly acting antidepressants: breaking the speed of sound or light?

journal contribution
posted on 2018-11-01, 00:00 authored by Michael BerkMichael Berk, Collen Loo, Christopher G Davey, Brian H Harvey
There is an urgent need for rapidly acting antidepressants. Current therapies share a delayed onset of action, contrasting with drugs of abuse that have rapid psychotropic effects but cause tolerance and dependence. A key uncertainty is whether there is a finite speed limit imposed by the critical role of homeostatic adaptive mechanisms that underpin the efficacy and onset of available psychotropic agents and whether this is mutable with emerging agents with potential rapid onset, in particular ketamine.

History

Journal

Australian and New Zealand journal of psychiatry

Volume

52

Issue

11

Pagination

1026 - 1029

Publisher

SAGE Publications

Location

London, Eng.

eISSN

1440-1614

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2018, The Royal Australian and New Zealand College of Psychiatrists