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Killer T cells in influenza

journal contribution
posted on 2008-11-01, 00:00 authored by John StambasJohn Stambas, C Guillonneau, K Kedzierska, J Mintern, P Doherty, N La Gruta
Antigen-specific CD8+ T cells play an important role in virus clearance. Here we review the current understanding of influenza virus-specific CD8+ T cell immunity in experimental mouse models and humans. The characteristics and nature of CD8+ T cell killing are discussed, as is the selection and maintenance of the influenza-specific effector and memory repertoires. Consideration is given to vaccine strategies and to the effects of ageing. Understanding the complexities of CD8+ T cell mediated immunity and memory has the potential for improving vaccine design, particularly to combat pandemics caused by newly emerging influenza viruses.

History

Journal

Pharmacology and Therapeutics

Volume

120

Issue

2

Pagination

186 - 196

Publisher

Elsevier Ltd.

Location

Oxford, England

ISSN

0163-7258

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

Copyright 2010 Elsevier Inc. All rights reserved.