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Killer T cells in influenza
journal contribution
posted on 2008-11-01, 00:00 authored by John StambasJohn Stambas, C Guillonneau, K Kedzierska, J Mintern, P Doherty, N La GrutaAntigen-specific CD8+ T cells play an important role in virus clearance. Here we review the current understanding of influenza virus-specific CD8+ T cell immunity in experimental mouse models and humans. The characteristics and nature of CD8+ T cell killing are discussed, as is the selection and maintenance of the influenza-specific effector and memory repertoires. Consideration is given to vaccine strategies and to the effects of ageing. Understanding the complexities of CD8+ T cell mediated immunity and memory has the potential for improving vaccine design, particularly to combat pandemics caused by newly emerging influenza viruses.
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Journal
Pharmacology and TherapeuticsVolume
120Issue
2Pagination
186 - 196Publisher
Elsevier Ltd.Location
Oxford, EnglandPublisher DOI
ISSN
0163-7258Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
Copyright 2010 Elsevier Inc. All rights reserved.Usage metrics
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InfluenzaCD8+ T cellsCytotoxicityMemoryTCR repertoireVaccineAgeingScience & TechnologyLife Sciences & BiomedicinePharmacology & PharmacyCD8+T cellsA-VIRUSIN-VIVOLYMPHOCYTIC CHORIOMENINGITISREPERTOIRE DIVERSITYPROTECTIVE IMMUNITYHLA-B35-RESTRICTED EPITOPERECEPTOR REPERTOIRESEQUENCE VARIATIONANTIBODY-RESPONSEHUMORAL IMMUNITY
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