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Kiss and break up—a safe passage to anaphase in mitosis and meiosis
journal contribution
posted on 2005-09-01, 00:00 authored by Jeffrey CraigJeffrey Craig, K H Andy ChooEukaryotic chromosomes have many challenges to overcome between DNA replication and sister chromatid segregation. If these challenges are not met, cell death or unregulated cell division (cancer) may result. During prophase, chromosomes condense, the nuclear membrane breaks down and cohesins are removed from chromosome arms. In prometaphase, initial spindle attachments are made by sister kinetochores followed by correction of erroneous attachments, centromere oscillation between spindle poles and congression towards the cell's equator. In metaphase, all chromosomes attain stable bipolar spindle attachments and align at the metaphase plate, ready for the metaphase-anaphase transition when all ties between sister chromatids are broken. This review concentrates on recent developments that have revealed the intricacies of these processes. We now know more about how the mechanisms of cohesin removal differ between prophase and the metaphase-anaphase transition, the processes for detection and correction of improper spindle-kinetochore attachments and the concept that tension between sister kinetochores is the driving factor for satisfying the spindle checkpoint. We are also beginning to gain some understanding of the mechanisms behind the co-segregation of sister chromatids at the first meiotic division.
History
Journal
ChromosomaVolume
114Issue
4Pagination
252 - 262Publisher
SpringerLocation
Berlin, GermanyPublisher DOI
ISSN
0009-5915Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2005, Springer-VerlagUsage metrics
Categories
Keywords
AnaphaseAnimalsCell CycleDNA ReplicationHumansMeiosisMitosisProteinsSaccharomyces cerevisiaeSister ChromatidFission YeastKinetochore ProteinSpindle CheckpointCohesin ComplexScience & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyGenetics & HereditySISTER-CHROMATID COHESIONKINETOCHORE-MICROTUBULE INTERFACECHROMOSOME SEGREGATIONTOPOISOMERASE-IICELL-DIVISIONCENTROMERIC COHESIONMITOTIC CHROMOSOMESDNA TOPOISOMERASEOUTER KINETOCHORECDC14 PHOSPHATASEGenetics
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