Background: The coronavirus has developed into a global public emergency. Different preventive measures like handwashing stations, isolation chambers, and personal protective equipment are frequently insufficient in prisons and detention facilities. Furthermore, there were significant dangers of infection from close contact with incarcerated people and prison and detention center staff. The purpose of this study was to evaluate the awareness of COVID-19 prevention strategies among correctional facility staff in the Bench-Sheko Zone, southwest Ethiopia. Methods: Between May and June 2020, an institutional-based cross-sectional study was carried out among selected individuals who were correctional facility staff located in the Bench-Sheko zone at the time the data were collected. The study participants were chosen using a stratified systematic random sampling technique. Epi-data 3.1 was used to enter the data, and SPSS version 22 was used to analyze it. To find a candidate and an independent factor, respectively, bivariate and multivariable logistic regression analyses were utilized. Results: The levels of knowledge and practice toward COVID-19 were 41.5% and 39.5% respectively. Working in detention [AOR: 4.7, 95% CI: 2.1-10.5)] was also a risk factor for poor knowledge, and among the population working in detention, rural residence [AOR: 5.6, 95% CI: 2.2-14.3)], and lower educational level [AOR: 9.4, 95% CI: 3.3-26.9)] were additional risk factors for poor knowledge. Furthermore, for people working in detention, lower education levels [AOR: 4.3, 95% CI: 1.3-14)], poor knowledge [AOR: 3.3, 95% CI: 1.6-6.8)], and poor attitude [AOR: 9.1, 95% CI: 1.9-43.7)], were associated with poor preventive practice. Conclusion and recommendation: Prison and detention center staff had poor knowledge and preventive measures toward COVID-19. An upcoming educational intervention is recommended to raise awareness of the diseases. Moreover, the decarcerating strategy also needs to be considered to mitigate COVID.