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Krill oil has different effects on the plasma lipidome compared with fish oil following 30 days of supplementation in healthy women: A randomized controlled and crossover study
journal contributionposted on 2023-11-21, 04:34 authored by HH Sung, Andrew SinclairAndrew Sinclair, K Huynh, AAT Smith, NA Mellett, PJ Meikle, XQ Su
This is a follow-up of our previous postprandial study and it focused on the plasma lipidomic responses to 30 days of krill oil (KO) versus fish oil (FO) supplementations in healthy women. Eleven women (aged 18–50 years) consumed KO or FO for 30 days in a randomized, cross-over study, with at least a four-week washout period between supplementations. The daily supplements provided 1.27 g/day of long-chain (LC) omega-3 polyunsaturated fatty acids (PUFA) from KO (containing 0.76 g eicosapentaenoic acid (EPA), 0.42 g docosahexaenoic acid (DHA)) and 1.44 g/day from FO (containing 0.79 g EPA, 0.47 g DHA). Fasting plasma samples at days 0, 15, and 30 were analyzed using gas chromatography and liquid chromatography electrospray ionisation-tandem mass spectrometry. KO resulted in a significantly greater relative area under the curve (relAUC) for plasma EPA after 30 days. Lipidomic analysis showed that 26 of 43 lipid molecular species had a significantly greater relAUC in the KO group, while 17/43 showed a significantly lower relAUC compared with the FO group. More than 38% of the lipids species which increased more following KO contained omega-3 PUFA, while where FO was greater than KO, only 12% contained omega-3 PUFA. These data show that KO and FO do not have equivalent effects on the plasma lipidome.
Article numberARTN 2804
Science & TechnologyLife Sciences & BiomedicineNutrition & Dieteticskrill oilfish oilplasma lipidomic responseEPADHAphospholipidsphosphatidylcholine30-day studywomenlipidomeEICOSAPENTAENOIC ACID EPADOCOSAHEXAENOIC ACIDBIOAVAILABILITYCONSUMPTIONAdultAnimalsArea Under CurveCross-Over StudiesDietary SupplementsDocosahexaenoic AcidsEicosapentaenoic AcidEuphausiaceaFatty Acids, Omega-3FemaleFish OilsHumansLipidomicsLipidsPhospholipidsPlasmaYoung AdultPreventionNutritionClinical ResearchComplementary and Integrative Health3 Prevention of disease and conditions, and promotion of well-being3.3 Nutrition and chemoprevention