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Lab-on-paper micro- and nano-analytical devices: fabrication, modification, detection and emerging applications

journal contribution
posted on 2016-05-01, 00:00 authored by Y Xu, M Liu, Na Kong, J Liu
Paper-based chips (PB-chips; also referred to as lab-on-paper chips) are using patterned paper as a substrate in a lab-on-a-chip platform. They represent an outstanding technique for fabrication of analytical devices for multiplex analyte assays. Typical features include low-cost, portability, disposability and small sample consumption. This review (with 211 refs.) gives a comprehensive and critical insight into current trends in terms of materials and techniques for use in fabrication, modification and detection. Following an introduction into the principles of PB-chips, we discuss features of using paper in lab-on-a-chip devices and the proper choice of paper. We then discuss the versatile methods known for fabrication of PB-chips (ranging from photolithography, plasma treatment, inkjet etching, plotting, to printing including flexographic printing). The modification of PB-chips with micro- and nano-materials possessing superior optical or electronic properties is then reviewed, and the final section covers detection techniques (such as colorimetry, electrochemistry, electrochemiluminescence and chemiluminescence) along with specific (bio)analytical examples. A conclusion and outlook section discusses the challenges and future prospectives in this field. [Figure not available: see fulltext.]

History

Journal

Microchimica acta

Volume

183

Issue

5

Pagination

1521 - 1542

Publisher

Springer Verlag

Location

Vienna, Austria

ISSN

0026-3672

eISSN

1436-5073

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2016, Springer-Verlag Wien

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