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Layer-by-layer assembly of silica nanoparticles on 3D fibrous scaffolds : enhancement of osteoblast cell adhesion, proliferation, and differentiation

journal contribution
posted on 2014-11-01, 00:00 authored by Yanwei Tang, Yan Zhao, Xungai Wang, Tong Lin
Silica nanoparticles were applied onto the fiber surface of an interbonded three-dimensional polycaprolactone fibrous tissue scaffold by an electrostatic layer-by-layer self-assembly technique. The nanoparticle layer was found to improve the fiber wettability and surface roughness. Osteoblast cells were cultured on the fibrous scaffolds to evaluate the biological compatibility. The silica nanoparticle coated scaffold showed enhanced cell attachment, proliferation, and alkaline phosphatase activities. The overall results suggested that interbonded fibrous scaffold with silica nanoparticulate coating could be a promising scaffolding candidate for various applications in bone repair and regeneration.

History

Journal

Journal of Biomedical Materials Research - Part A

Volume

102

Issue

11

Pagination

3803 - 3812

Publisher

John Wiley & Sons

Location

NJ, United States

eISSN

1552-4965

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2014, John Wiley & Sons