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Layer-by-layer assembly of silica nanoparticles on 3D fibrous scaffolds : enhancement of osteoblast cell adhesion, proliferation, and differentiation
journal contribution
posted on 2014-11-01, 00:00 authored by Yanwei Tang, Yan Zhao, Xungai Wang, Tong LinSilica nanoparticles were applied onto the fiber surface of an interbonded three-dimensional polycaprolactone fibrous tissue scaffold by an electrostatic layer-by-layer self-assembly technique. The nanoparticle layer was found to improve the fiber wettability and surface roughness. Osteoblast cells were cultured on the fibrous scaffolds to evaluate the biological compatibility. The silica nanoparticle coated scaffold showed enhanced cell attachment, proliferation, and alkaline phosphatase activities. The overall results suggested that interbonded fibrous scaffold with silica nanoparticulate coating could be a promising scaffolding candidate for various applications in bone repair and regeneration.
History
Journal
Journal of Biomedical Materials Research - Part AVolume
102Issue
11Pagination
3803 - 3812Publisher
John Wiley & SonsLocation
NJ, United StatesPublisher DOI
eISSN
1552-4965Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2014, John Wiley & SonsUsage metrics
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