brown-learningfromscaling-2021.pdf (2.75 MB)
Learning from scaling up ultra-rapid genomic testing for critically ill children to a national level
journal contribution
posted on 2021-01-01, 00:00 authored by S Best, Helen BrownHelen Brown, S Lunke, C Patel, J Pinner, C P Barnett, M Wilson, S A Sandaradura, B McClaren, G R Brett, J Braithwaite, Z StarkIn scaling up an ultra-rapid genomics program, we used implementation science principles to design and investigate influences on implementation and identify strategies required for sustainable “real-world” services. Interviews with key professionals revealed the importance of networks and relationship building, leadership, culture, and the relative advantage afforded by ultra-rapid genomics in the care of critically ill children. Although clinical geneticists focused on intervention characteristics and the fit with patient-centered care, intensivists emphasized the importance of access to knowledge, in particular from clinical geneticists. The relative advantage of ultra-rapid genomics and trust in consistent and transparent delivery were significant in creating engagement at initial implementation, with appropriate resourcing highlighted as important for longer term sustainability of implementation. Our findings demonstrate where common approaches can be used and, significantly, where there is a need to tailor support by professional role and implementation phase, to maximize the potential of ultra-rapid genomic testing to improve patient care.
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npj Genomic MedicineVolume
6Issue
1Article number
5Pagination
1 - 9Publisher
Nature Publishing GroupLocation
London, Eng.Publisher DOI
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2056-7944eISSN
2056-7944Language
EnglishPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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