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Leptin resistance in a polygenic, hyperleptinemic animal model of obesity and NIDDM : Psammomys obesus

journal contribution
posted on 1999-01-01, 00:00 authored by Ken WalderKen Walder, Paul Lewandowski, G Morton, A Sanigorski, A de Silva, P Zimmet, Gregory Collier
OBJECTIVE: To investigate the effects of leptin administration to Psammomys obesus, a polygenic animal model of obesity and type 2 diabetes mellitus.

DESIGN: Longitudinal intervention study utilising three separate leptin treatment protocols lasting 7-14 d.

MEASUREMENTS: Body weight and food intake were measured daily, body fat and muscle content were estimated by carcass analysis on completion of the study. Blood glucose, plasma insulin, leptin, triglycerides and cholesterol were measured at baseline and twice each week during the study.

RESULTS: Relatively high doses of leptin were required to significantly reduce food intake and body fat content in lean Psammomys obesus, but had no discernible effect on their obese littermates.

CONCLUSION: As a species, Psammomys obesus appear to be relatively insensitive to the effects of leptin administration, compared with other rodents. Obese Psammomys obesus are leptin resistant relative to their lean littermates.

History

Journal

International journal of obesity

Volume

23

Issue

1

Pagination

83 - 89

Publisher

Nature Publishing Group

Location

London, England

ISSN

0307-0565

eISSN

1476-5497

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal