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Lesion network mapping for symptom localization: Recent developments and future directions
journal contribution
posted on 2023-03-01, 22:41 authored by J Joutsa, Daniel CorpDaniel Corp, MD FoxPurpose of reviewFocal lesions causing specific neurological or psychiatric symptoms can occur in multiple different brain locations, complicating symptom localization. Here, we review lesion network mapping, a technique used to aid localization by mapping lesion-induced symptoms to brain circuits rather than individual brain regions. We highlight recent examples of how this technique is being used to investigate clinical entities and identify therapeutic targets.Recent findingsTo date, lesion network mapping has successfully been applied to more than 40 different symptoms or symptom complexes. In each case, lesion locations were combined with an atlas of human brain connections (the human connectome) to map heterogeneous lesion locations causing the same symptom to a common brain circuit. This approach has lent insight into symptoms that have been difficult to localize using other techniques, such as hallucinations, tics, blindsight, and pathological laughter and crying. Further, lesion network mapping has recently been applied to lesions that improve symptoms, such as tremor and addiction, which may translate into new therapeutic targets.SummaryLesion network mapping can be used to map lesion-induced symptoms to brain circuits rather than single brain regions. Recent findings have provided insight into long-standing clinical mysteries and identified testable treatment targets for circuit-based and symptom-based neuromodulation.
History
Journal
Current Opinion in NeurologyVolume
35Pagination
453-459Location
EnglandPublisher DOI
ISSN
1350-7540eISSN
1473-6551Language
EnglishPublication classification
C1 Refereed article in a scholarly journalIssue
4Publisher
LIPPINCOTT WILLIAMS & WILKINSUsage metrics
Keywords
Science & TechnologyLife Sciences & BiomedicineClinical NeurologyNeurosciencesNeurosciences & Neurologyconnectivitydiaschisislesionlesion network mappinglocalizationnetworkneuroimagingsymptomTRANSCRANIAL MAGNETIC STIMULATIONBRAIN-LESIONSBrainBrain MappingConnectomeForecastingHumansTremorMagnetic Resonance ImagingBrain Disorders2 Aetiology2.1 Biological and endogenous factorsNeurologicalCognitive SciencesClinical Sciences not elsewhere classifiedNeurosciences not elsewhere classified
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