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Linking the serotonin transporter gene, family environments, hippocampal volume and depression onset: a prospective imaging gene × environment analysis
journal contribution
posted on 2015-11-01, 00:00 authored by Keri LittleKeri Little, Craig OlssonCraig Olsson, George YoussefGeorge Youssef, S Whittle, J G Simmons, M Yücel, L B Sheeber, D L Foley, N B AllenA single imaging gene-environment (IGxE) framework that is able to simultaneously model genetic, neurobiological, and environmental influences on psychopathology outcomes is needed to improve understanding of how complex interrelationships between allelic variation, differences in neuroanatomy or neuroactivity, and environmental experience affect risk for psychiatric disorder. In a longitudinal study of adolescent development we demonstrate the utility of such an IGxE framework by testing whether variation in parental behavior at age 12 altered the strength of an imaging genetics pathway, involving an indirect association between allelic variation in the serotonin transporter gene to variation in hippocampal volume and consequent onset of major depressive disorder by age 18. Results were consistent with the presence of an indirect effect of the serotonin transporter S-allele on depression onset via smaller left and right hippocampal volumes that was significant only in family environments involving either higher levels of parental aggression or lower levels of positive parenting. The previously reported finding of S-allele carriers' increased risk of depression in adverse environments may, therefore, be partly because of the effects of these environments on a neurobiological pathway from the serotonin transporter gene to depression onset that proceeds through variation in hippocampal volume.
History
Journal
Journal of abnormal psychologyVolume
124Issue
4Pagination
834 - 849Publisher
American Psychological AssociationLocation
Washington, D. C.Publisher DOI
eISSN
1939-1846Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2015, APAUsage metrics
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No categories selectedKeywords
Social SciencesScience & TechnologyLife Sciences & BiomedicinePsychology, ClinicalPsychiatryPsychology, MultidisciplinaryPsychologyimaging gene X environment :frameworkserotonin transporter genemajor depressive disorderfamily environmenthippocampus5-HTTLPR POLYMORPHISMSTATISTICAL POWERBRAIN-DEVELOPMENTLONG VARIANTSTRESSCHILDHOODAMYGDALADISORDERRISKWOMEN
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