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Lipid merging, protrusion and vesicle release triggered by shrinking/swelling of poly(N-isopropylacrylamide) microgel particles
journal contribution
posted on 2014-03-30, 00:00 authored by Y Dou, Jingliang LiJingliang Li, B Yuan, K YangCell membrane changes its morphology during many physiological processes with the assistance of a solid support, such as the cytoskeleton, under an environmental stimulus. Here, a novel type of stimuli-responsive lipogel was fabricated, mimicking the changes of cell membrane. The lipogel was prepared from poly(N-isopropylacrylamide) (pNIPAM) microgel particle and phospholipid by a solvent-exchange method. The temperature dependent volume phase transition of pNIPAM triggers reversible transformation of the lipogel between a lipid vesicle-coated sun-like structure and a contracted hybrid sphere, through lipid merging and protrusion processes, respectively. By contrast, the salt induced pNIPAM phase transition leads to an irreversible vesicle release behaviour. The lipogel creates a unique platform for studying cell membrane behaviour and provides promising candidates in drug delivery and controlled release applications. © 2014 Elsevier B.V. All rights reserved.
History
Journal
Applied surface scienceVolume
296Pagination
95 - 99Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0169-4332Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2014, ElsevierUsage metrics
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No categories selectedKeywords
Controlled releaseLipid mergingpNIPAM particleTransformationScience & TechnologyPhysical SciencesTechnologyChemistry, PhysicalMaterials Science, Coatings & FilmsPhysics, AppliedPhysics, Condensed MatterChemistryMaterials SciencePhysicsGIANT UNILAMELLAR VESICLESN-ISOPROPYLACRYLAMIDECOMPUTER-SIMULATIONCELLULAR UPTAKENANOPARTICLESBILAYERMACROMOLECULESTRANSITIONMEMBRANESPOLYMERS
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