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Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?

journal contribution
posted on 11.09.2003, 00:00 authored by Aaron RussellAaron Russell, G Gastaldi, E Bobbioni-Harsch, P Arboit, C Gobelet, O Deriaz, A Golay, J Witztum, J P Giacobino
Intra-myocellular triglycerides (IMTG) accumulate in the muscle of obese and endurance-trained (ET) humans and are considered a pathogenic factor in the development of insulin resistance, in the former. We postulate that this paradox may be associated with the peroxidation status of the IMTG. IMTG content was the same in the obese and ET subjects. The lipid peroxidation/IMTG ratio was 4.2-fold higher in the obese subjects. Hence, obesity results in an increased level of IMTG peroxidation while ET has a protective effect on IMTG peroxidation. This suggests a link between the lipid peroxidation/IMTG ratio and insulin resistance.


History

Journal

FEBS letter

Volume

551

Issue

1-3

Pagination

104 - 106

Publisher

Elsevier BV

Location

Amsterdam, The Netherlands

ISSN

0014-5793

eISSN

1873-3468

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2003, Federation of European Biochemical Societies