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Lithium blocks 45Ca2+ uptake into platelets in bipolar affective disorder and controls.
journal contributionposted on 1996-02-01, 00:00 authored by Michael BerkMichael Berk, N H Kirchmann, N Butkow
The basal uptake of radiolabelled 45Ca2+ into platelets and the effect of 1 mM lithium on uptake was measured in manic (n = 13) and depressed (n = 15) patients with bipolar disorder and in controls (n = 13). Lithium was significantly associated with inhibition of uptake of 45Ca2+ into platelets in all three groups. There were no significant intergroup differences in either basal levels of calcium uptake or the effects of lithium on calcium uptake (analysis of variance).