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Location rather than CD62L phenotype is critical in the early establishment of influenza-specific T cell memory

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journal contribution
posted on 2007-06-01, 00:00 authored by K Kedzierska, John StambasJohn Stambas, M Jenkins, R Keating, S Turner, P Doherty
The rapid recall of influenza virus-specific CD8+ T cell effector function is protective, although our understanding of T cell memory remains incomplete. Recent debate has focused particularly on the CD62L lymph node homing receptor. The present analysis shows that although functional memory can be established from both CD62Lhi and CD62Llo CD8+ T cell subsets soon after initial encounter between naive precursors and antigen, the optimal precursors are CD8+CD44hiCD25lo immune lymphocytes isolated from draining lymph nodes on day 3.5 after influenza virus infection. Analysis of primed T cells at different times after challenge indicates that the capacity to transfer memory is diminished at the peak of the primary cytotoxic T lymphocyte response, challenging speculations that the transition to memory first requires full differentiation to effector status. It seems that location rather than CD62Lhi/lo phenotype may be the more profitable focus for further dissection of the early establishment of T cell memory.

History

Journal

Proceedings of the National Academy of Sciences of the United States of America

Volume

104

Pagination

9782 - 9787

Location

Washington, D.C.

Open access

  • Yes

ISSN

0027-8424

eISSN

1091-6490

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2007 by The National Academy of Sciences of the USA