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Long-term effectiveness of a lifestyle intervention on the prevention of type 2 diabetes in a middle-income country
journal contribution
posted on 2020-08-25, 00:00 authored by Mojtaba Lotfaliany Abrand AbadiMojtaba Lotfaliany Abrand Abadi, M A Mansournia, F Azizi, F Hadaegh, N Zafari, A Ghanbarian, P Mirmiran, B Oldenburg, D KhaliliThis study aims to assess the effects of a community-based lifestyle intervention program on the incidence of type 2 diabetes (T2D). For this purpose, three communities in Tehran were chosen; one community received a face-to-face educational session embedded in a long-term community-wide lifestyle intervention aimed at supporting lifestyle changes. We followed up 9,204 participants (control: 5,739, intervention: 3,465) triennially from 1999 to 2015 (Waves 1–5). After a median follow-up of 3.5 years (wave 2), the risk of T2D was 30% lower in the intervention community as compared with two control communities by (Hazard-ratio: 0.70 [95% CI 0.53; 0.91]); however, the difference was not statistically significant in the following waves. After a median follow-up of 11.9 years (wave 5), there was a non-significant 6% reduction in the incidence of T2D in the intervention group as compared to the control group (Hazard-ratio: 0.94 [0.81, 1.08]). Moreover, after 11.9 years of follow-up, the intervention significantly improved the diet quality measured by the Dietary Approaches to Stop Hypertension concordance (DASH) score. Mean difference in DASH score in the intervention group versus control group was 0.2 [95% CI 0.1; 0.3]. In conclusion, the intervention prevented T2D by 30% in the short-term (3.5 years) but not long-term; however, effects on improvement of the diet maintained in the long-term.
Registration: This study is registered at IRCT, a WHO primary registry (https://irct.ir). The registration date 39 is 2008-10-29 and the IRCT registration number is IRCT138705301058N1.
Registration: This study is registered at IRCT, a WHO primary registry (https://irct.ir). The registration date 39 is 2008-10-29 and the IRCT registration number is IRCT138705301058N1.
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Journal
Scientific ReportsVolume
10Issue
1Article number
14173Pagination
1 - 10Publisher
Nature ResearchLocation
Berlin, GermanyPublisher DOI
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ISSN
2045-2322eISSN
2045-2322Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2020, The Author(s)Usage metrics
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