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Long-term effects of a reduced fat diet intervention on cardiovascular disease risk factors in individuals with glucose intolerance

journal contribution
posted on 2004-02-01, 00:00 authored by S Ley, P Metcalf, R Scragg, Boyd SwinburnBoyd Swinburn
The long-term effects on cardiovascular disease risk factors of a reduced fat (RF), ad libitum diet were compared with usual diet (control, CD) in glucose intolerance individuals.

Participants were 136 adults aged ≥40 years with ‘glucose intolerance’ (2 h blood glucose 7–11.0 mmol/l) detected at a Diabetes Survey who completed at 1 year intervention study of reduced fat, ad libitum diet versus usual diet. They were re-assessed at 2, 3 and 5 years. Main outcome measures were blood pressure, serum concentrations of total cholesterol, HDL and LDL cholesterol, total cholesterol:HDL ratio, triglycerides and body weight.

The reduced fat diet lowered total cholesterol (P<0.01), LDL cholesterol (P≤0.05), total cholesterol:HDL ratio (P≤0.05), body weight (P<0.01) and systolic blood pressure (P≤0.05) initially and diastolic blood pressure (P<0.01) long-term. No significant changes occurred in HDL cholesterol or triglycerides. In the more compliant 50% of the intervention group, systolic and diastolic blood pressure levels and body weight were lower at 1, 2 and 3 years (P<0.05).

It was concluded that a reduced fat ad libitum diet has short-term benefits for cholesterol, body weight and systolic blood pressure and long-term benefits for diastolic blood pressure without significantly effecting HDL cholesterol and triglycerides despite participants regaining their lost weight.

History

Journal

Diabetes research and clinical practice

Volume

2004, No 63

Issue

63

Season

2

Pagination

103 - 112

Publisher

Elsevier Ireland Ltd

Location

Ireland

ISSN

0168-8227

eISSN

1872-8227

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2003, Elsevier Ireland

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