File(s) under permanent embargo
Longitudinal change in white matter microstructure in Huntington's disease: The IMAGE-HD study
Version 2 2024-06-05, 06:47Version 2 2024-06-05, 06:47
Version 1 2020-01-30, 13:37Version 1 2020-01-30, 13:37
journal contribution
posted on 2024-06-05, 06:47 authored by GR Poudel, JC Stout, Juan Dominguez DuqueJuan Dominguez Duque, A Churchyard, P Chua, GF Egan, N Georgiou-Karistianis© 2014 Elsevier Inc. Objective: To quantify 18-month changes in white matter microstructure in premanifest (pre-HD) and symptomatic Huntington's disease (symp-HD). To investigate baseline clinical, cognitive and motor symptoms that are predictive of white matter microstructural change over 18. months. Method: Diffusion tensor imaging (DTI) data were analyzed for 28 pre-HD, 25 symp-HD, and 27 controls scanned at baseline and after 18. months. Unbiased tract-based spatial statistics (TBSS) methods were used to identify longitudinal changes in fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD) of white matter. Stepwise linear regression models were used to identify baseline clinical, cognitive, and motor measures that are predictive of longitudinal diffusion changes. Results: Symp-HD compared to controls showed 18-month reductions in FA in the corpus callosum and cingulum white matter. Symp-HD compared to pre-HD showed increased RD in the corpus callosum and striatal projection pathways. FA in the body, genu, and splenium of the corpus callosum was significantly associated with a baseline clinical motor measure (Unified Huntington's Disease Rating Scale: total motor scores: UHDRS-TMS) across both HD groups. This measure was also the only independent predictor of longitudinal decline in FA in all parts of the corpus callosum across both HD groups. Conclusions: We provide direct evidence of longitudinal decline in white matter microstructure in symp-HD. Although pre-HD did not show longitudinal change, clinical symptoms and motor function predicted white matter microstructural changes for all gene positive subjects. These findings suggest that loss of axonal integrity is an early hallmark of neurodegenerative changes which are clinically relevant.
History
Journal
Neurobiology of DiseaseVolume
74Pagination
406-412Location
Amsterdam, The NetherlandsPublisher DOI
ISSN
0969-9961eISSN
1095-953XLanguage
engPublication classification
C1 Refereed article in a scholarly journalIssue
1Publisher
ElsevierUsage metrics
Licence
Exports
RefWorksRefWorks
BibTeXBibTeX
Ref. managerRef. manager
EndnoteEndnote
DataCiteDataCite
NLMNLM
DCDC