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Longitudinal developmental trajectories of inhibition and white-matter maturation of the fronto-basal-ganglia circuits
journal contribution
posted on 2023-02-10, 04:57 authored by Mervyn SinghMervyn Singh, P Skippen, J He, P Thomson, Ian FuelscherIan Fuelscher, Karen CaeyenberghsKaren Caeyenberghs, V Anderson, JM Nicholson, Christian HydeChristian Hyde, Tim SilkTim SilkResponse inhibition refers to the cancelling of planned (or restraining of ongoing) actions and is required in much of our everyday life. Response inhibition appears to improve dramatically in early development and plateau in adolescence. The fronto-basal-ganglia network has long been shown to predict individual differences in the ability to enact response inhibition. In the current study, we examined whether developmental trajectories of fiber-specific white matter properties of the fronto-basal-ganglia network was predictive of parallel developmental trajectories of response inhibition. 138 children aged 9–14 completed the stop-signal task (SST). A subsample of 73 children underwent high-angular resolution diffusion MRI data for up to three time points. Performance on the SST was assessed using a parametric race modelling approach. White matter organization of the fronto-basal-ganglia circuit was estimated using fixel-based analysis. Contrary to predictions, we did not find any significant associations between maturational trajectories of fronto-basal-ganglia white matter and developmental improvements in SST performance. Findings suggest that the development of white matter organization of the fronto-basal-ganglia and development of stopping performance follow distinct maturational trajectories.
History
Journal
Developmental Cognitive NeuroscienceVolume
58Article number
101171Pagination
101171-101171Location
NetherlandsPublisher DOI
ISSN
1878-9293eISSN
1878-9307Language
enPublication classification
C1 Refereed article in a scholarly journalPublisher
Elsevier BVUsage metrics
Keywords
Childhood DevelopmentDiffusion MRIFixel-based analysisLongitudinal analysesResponse inhibitionStop-signal taskAdolescentChildHumansWhite MatterInhibition, PsychologicalBasal GangliaTask Performance and AnalysisGangliaPediatricCognitive SciencesClinical Sciences not elsewhere classifiedNeurosciences not elsewhere classified
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