File(s) not publicly available
Longitudinal effects of prenatal exposure to plastic-derived chemicals and their metabolites on asthma and lung function from childhood into adulthood
journal contribution
posted on 2023-02-10, 04:56 authored by RE Foong, P Franklin, F Sanna, GL Hall, Peter Sly, EB Thorstensen, DA Doherty, JA Keelan, RJ HartBackground and Objective: Environmental exposure to phthalates and bisphenol A (BPA), chemicals used in the production of plastics, may increase risk for asthma and allergies. However, little is known about the long-term effects of early life exposure to these compounds. We investigated if prenatal exposure to these compounds was associated with asthma, allergy and lung function outcomes from early childhood into adulthood in a cohort study. Methods: Maternal serum samples collected from 846 pregnant women in the Raine Study were assayed for BPA and phthalate metabolites. The children of these women were followed up at 5, 13 and 22 years where spirometry and respiratory questionnaires were conducted to determine asthma and allergy status. Lung function trajectories were derived from longitudinal spirometry measurements. Multinomial logistic regression and weighted quantile sum regression was used to test associations of individual and chemical mixtures with asthma phenotypes and lung function trajectories. Results: Effects of prenatal BPA and phthalates on asthma phenotypes were seen in male offspring, where BPA was associated with increased risk for persistent asthma, while mono-iso-butyl phthalate and mono-iso-decyl phthalate was associated with increased risk for adult asthma. Prenatal BPA had no effect on lung function trajectories, but prenatal phthalate exposure was associated with improved lung function. Conclusion: Prenatal BPA exposure was associated with increased likelihood of persistent asthma in males, while prenatal phthalate exposure was associated with increased likelihood of adult asthma in males. Results suggest that prenatal exposure to prenatal BPA and phthalates affect asthma risk, particularly in males, however lung function was not adversely affected.
History
Journal
RespirologyLocation
AustraliaPublisher DOI
ISSN
1323-7799eISSN
1440-1843Language
EnglishPublication classification
C1.1 Refereed article in a scholarly journalPublisher
WILEYUsage metrics
Categories
No categories selectedKeywords
ALLERGIC DISEASESasthmaATOPYBISPHENOL-A EXPOSURECHILDRENENDOCRINE-DISRUPTING CHEMICALSenvironmental exposureLife Sciences & Biomedicinelongitudinal birth cohort studylung functionpregnancyRespiratory SystemScience & Technologythe Raine studyLungPediatric Research InitiativeConditions Affecting the Embryonic and Fetal PeriodsPediatricPreventionClinical ResearchAsthma2.2 Factors relating to the physical environment2 AetiologyRespiratoryMedical and Health Sciences
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC