athan-lowincidenceof-2018.pdf (1.36 MB)
Low incidence of recurrent Buruli ulcers in treated Australian patients living in an endemic region
journal contribution
posted on 2018-08-01, 00:00 authored by James W Wynne, Timothy P Stinear, Eugene AthanEugene Athan, Wojtek P Michalski, Daniel O'BrienWe examined recurrent Buruli ulcer cases following treatment and assumed cure in a large cohort of Australian patients living in an endemic area. We report that while the recurrence rate was low (2.81 cases/year/1000 population), it remained similar to the estimated risk of primary infection within the general population of the endemic area (0.85-4.04 cases/year/1,000 population). The majority of recurrent lesions occurred in different regions of the body and were separated by a median time interval of 44 months. Clinical, treatment and epidemiological factors combined with whole genome sequencing of primary and recurrent isolates suggests that in most recurrent cases a re-infection was more likely as opposed to a relapse of the initial infection. Additionally, all cases occurring more than 12 months after commencement of treatment were likely re-infections. Our study provides important prognostic information for patients and their health care providers concerning the nature and risks associated with recurrent cases of Buruli ulcer in Australia.
History
Journal
PLoS neglected tropical diseasesVolume
12Issue
8Article number
e0006724Publisher
Public Library of ScienceLocation
San Francisco, Calif.Publisher DOI
Link to full text
ISSN
1935-2727eISSN
1935-2735Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2018, Wynne et al.Usage metrics
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