Deakin University
Browse

Luteolin, a flavonoid, as an anticancer agent: a review

Download (1.24 MB)
Version 2 2024-06-06, 08:24
Version 1 2019-08-09, 12:09
journal contribution
posted on 2024-06-06, 08:24 authored by M Imran, A Rauf, T Abu-Izneid, M Nadeem, MA Shariati, IA Khan, A Imran, IE Orhan, M Rizwan, M Atif, TA Gondal, MS Mubarak
Many food-derived phytochemicals and their derivatives represent a cornucopia of new anti-cancer compounds. Luteolin (3,4,5,7-tetrahydroxy flavone) is a flavonoid found in different plants such as vegetables, medicinal herbs, and fruits. It acts as an anticancer agent against various types of human malignancies such as lung, breast, glioblastoma, prostate, colon, and pancreatic cancers. It also blocks cancer development in vitro and in vivo by inhibition of proliferation of tumor cells, protection from carcinogenic stimuli, and activation of cell cycle arrest, and by inducing apoptosis through different signaling pathways. Luteolin can additionally reverse epithelial-mesenchymal transition (EMT) through a mechanism that involves cytoskeleton shrinkage, induction of the epithelial biomarker E-cadherin expression, and by down-regulation of the mesenchymal biomarkers N-cadherin, snail, and vimentin. Furthermore, luteolin increases levels of intracellular reactive oxygen species (ROS) by activation of lethal endoplasmic reticulum stress response and mitochondrial dysfunction in glioblastoma cells, and by activation of ER stress-associated proteins expressions, including phosphorylation of eIF2α, PERK, CHOP, ATF4, and cleaved-caspase 12. Accordingly, the present review article summarizes the progress of recent research on luteolin against several human cancers.

History

Journal

Biomedicine and pharmacotherapy

Volume

112

Article number

108612

Pagination

1-10

Location

Amsterdam, The Netherlands

Open access

  • Yes

ISSN

0753-3322

eISSN

1950-6007

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2019, Elsevier Masson SAS

Publisher

Elsevier

Usage metrics

    Research Publications

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC