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MAP kinase signalling pathways in cancer

journal contribution
posted on 2007-05-14, 00:00 authored by Amardeep DhillonAmardeep Dhillon, S Hagan, O Rath, W Kolch
Cancer can be perceived as a disease of communication between and within cells. The aberrations are pleiotropic, but mitogen-activated protein kinase (MAPK) pathways feature prominently. Here, we discuss recent findings and hypotheses on the role of MAPK pathways in cancer. Cancerous mutations in MAPK pathways are frequently mostly affecting Ras and B-Raf in the extracellular signal-regulated kinase pathway. Stress-activated pathways, such as Jun N-terminal kinase and p38, largely seem to counteract malignant transformation. The balance and integration between these signals may widely vary in different tumours, but are important for the outcome and the sensitivity to drug therapy. © 2007 Nature Publishing Group All rights reserved.

History

Journal

Oncogene

Volume

26

Issue

22

Pagination

3279 - 3290

ISSN

0950-9232

eISSN

1476-5594

Publication classification

C1.1 Refereed article in a scholarly journal