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MAP kinase signalling pathways in cancer
journal contribution
posted on 2007-05-14, 00:00 authored by Amardeep DhillonAmardeep Dhillon, S Hagan, O Rath, W KolchCancer can be perceived as a disease of communication between and within cells. The aberrations are pleiotropic, but mitogen-activated protein kinase (MAPK) pathways feature prominently. Here, we discuss recent findings and hypotheses on the role of MAPK pathways in cancer. Cancerous mutations in MAPK pathways are frequently mostly affecting Ras and B-Raf in the extracellular signal-regulated kinase pathway. Stress-activated pathways, such as Jun N-terminal kinase and p38, largely seem to counteract malignant transformation. The balance and integration between these signals may widely vary in different tumours, but are important for the outcome and the sensitivity to drug therapy. © 2007 Nature Publishing Group All rights reserved.
History
Journal
OncogeneVolume
26Issue
22Pagination
3279 - 3290Publisher DOI
ISSN
0950-9232eISSN
1476-5594Publication classification
C1.1 Refereed article in a scholarly journalUsage metrics
Categories
Keywords
Science & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyOncologyCell BiologyGenetics & HeredityMAPKcancersignal transductiononcogenesACTIVATED PROTEIN-KINASECELL-CYCLE ARRESTNF-KAPPA-BMETASTASIS SUPPRESSOR GENECROSS-CASCADE ACTIVATIONC-JUNHEPATOCELLULAR-CARCINOMATRANSDUCTION PATHWAYTUMOR-SUPPRESSORREGULATED KINASE