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Mammalian centromeres: DNA sequence, protein composition, and role in cell cycle progression
journal contribution
posted on 1999-02-01, 00:00 authored by Jeffrey CraigJeffrey Craig, W C Earnshaw, P VagnarelliThe centromere is a specialized region of the eukaryotic chromosome that is responsible for directing chromosome movements in mitosis and for coordinating the progression of mitotic events at the crucial transition between metaphase and anaphase. In this review, we will focus on recent advances in the understanding of centromere composition at the protein and DNA level and of the role of centromeres in sister-chromatid cohesion and mitotic checkpoint control.
History
Journal
Experimental cell researchVolume
246Issue
2Pagination
249 - 262Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0014-4827Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
1999, Academic PressUsage metrics
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No categories selectedKeywords
AnimalsCell CycleCentromereChromatidsDNAHumansKinetochoresMammalsProteinsSignal TransductionScience & TechnologyLife Sciences & BiomedicineOncologyCell BiologyALPHA-SATELLITE DNASISTER-CHROMATID SEPARATIONSPINDLE ASSEMBLY CHECKPOINTCLEAVAGE FURROW FORMATIONINNER KINETOCHORE PLATECENP-CCHROMOSOME SEGREGATIONFISSION YEASTSACCHAROMYCES-CEREVISIAEBUDDING YEAST
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