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Maternal birthweight and outcome of twin pregnancy
journal contribution
posted on 2007-11-01, 00:00 authored by Ruth Morley, Vivienne M Moore, Terence Dwyer, Julie OwensJulie Owens, Mark P Umstad, John B CarlinThere is evidence from singletons that maternal birthweight is positively related to offspring gestational length and birthweight, and some evidence of an inverse relationship with preterm birth. Among twins very preterm birth is the major cause of neonatal mortality and of immediate and later morbidity, including neurodevelopmental impairment. We hypothesised that the relationship between maternal birthweight and gestational length would be more evident in twin than in singleton pregnancies, as there is more variation in gestation in the former. Among 131 singleton mothers carrying twins, there was weak evidence of a positive relationship between maternal birthweight and twin gestational length (+0.6 weeks [95% CI -0.05, +1.3] per kg increase in maternal birthweight, but stronger evidence among 56 of these who went into labour spontaneously (+1.9 weeks [+0.7, +3.1], P = 0.003 for interaction). In the latter group we estimated that the odds of very preterm birth (at <32 weeks) were reduced by 50% [95% CI 10%, 82%] per 250 g increase in maternal birthweight. In the whole cohort, and in this subgroup, maternal birthweight was strongly positively related to both twin offspring total birthweight and total placental weight. Our data, consistent with intergenerational programming of early development, suggest the possibility of a stronger and more clinically relevant association among twins than among singletons. Nevertheless, our sample size was modest and this finding needs to be confirmed in a larger cohort.
History
Journal
Paediatric and perinatal epidemiologyVolume
21Issue
6Pagination
501 - 506Publisher
WileyLocation
Chichester, Eng.Publisher DOI
ISSN
0269-5022Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2007, The AuthorsUsage metrics
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No categories selectedKeywords
Birth WeightBody HeightCohort StudiesFemaleGestational AgeHumansInfant, NewbornMaleOdds RatioOrgan SizePlacentaPregnancyPregnancy OutcomePregnancy, MultiplePremature BirthTwinsScience & TechnologyLife Sciences & BiomedicinePublic, Environmental & Occupational HealthObstetrics & GynecologyPediatricsmaternal brithweighttwin gestationtwin pretermtwin birthweightplacental weight4 ETHNIC-GROUPSGESTATIONAL-AGEINFANTGENERATIONSVALIDATIONSINGLETONSMOTHERSGROWTHCOHORTADULT
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