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Maternal carriage of Prevotella during pregnancy associates with protection against food allergy in the offspring

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Version 2 2024-06-04, 06:42
Version 1 2020-03-30, 08:43
journal contribution
posted on 2024-06-16, 09:26 authored by Peter VuillerminPeter Vuillermin, M O’Hely, Fiona CollierFiona Collier, KJ Allen, MLK Tang, LC Harrison, JB Carlin, R Saffery, S Ranganathan, PD Sly, Lawrence GrayLawrence Gray, J Molloy, A Pezic, M Conlon, D Topping, K Nelson, CR Mackay, L Macia, J Koplin, Samantha DawsonSamantha Dawson, M Moreno-Betancur, AL Ponsonby, S Vashee, M Torralba, A Gomez, T Dwyer, D Burgner, Mike ForresterMike Forrester, C Symeonides, E Bandala Sanchez
AbstractIn mice, the maternal microbiome influences fetal immune development and postnatal allergic outcomes. Westernized populations have high rates of allergic disease and low rates of gastrointestinal carriage of Prevotella, a commensal bacterial genus that produces short chain fatty acids and endotoxins, each of which may promote the development of fetal immune tolerance. In this study, we use a prebirth cohort (n = 1064 mothers) to conduct a nested case-cohort study comparing 58 mothers of babies with clinically proven food IgE mediated food allergy with 258 randomly selected mothers. Analysis of the V4 region of the 16S rRNA gene in fecal samples shows maternal carriage of Prevotella copri during pregnancy strongly predicts the absence of food allergy in the offspring. This association was confirmed using targeted qPCR and was independent of infant carriage of P. copri. Larger household size, which is a well-established protective factor for allergic disease, strongly predicts maternal carriage of P. copri.

History

Journal

Nature Communications

Volume

11

Article number

ARTN 1452

Location

England

Open access

  • Yes

ISSN

2041-1723

eISSN

2041-1723

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2020, The Authors

Issue

1

Publisher

NATURE PORTFOLIO

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