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Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS-CoV-2 infection in South Africa: An International Network of Obstetric Survey Systems-based cohort study

Version 2 2024-05-31, 00:57
Version 1 2023-08-09, 03:31
journal contribution
posted on 2023-08-09, 03:31 authored by S Budhram, V Vannevel, T Botha, L Chauke, S Bhoora, GM Balie, N Odell, H Lombaard, A Wise, C Georgiou, N Ngxola, E Wynne, U Mbewu, M Mabenge, S Phinzi, N Gubu-Ntaba, G Goldman, K Tunkyi, S Prithipal, K Naidoo, S Venkatachalam, T Moodley, S Mould, M Hlabisa, L Govender, C Maistry, JP Habineza, P Israel, S Foolchand, NV Tsibiyane, M Panday, P Soma-Pillay, S Adam, F Molokoane, MS Mojela, EJ van Rensburg, T Mashamba, M Matjila, S Fawcus, A Osman, M Venter, G Petro, A Fakier, E Langenegger, CA Cluver, A Bekker, L de Waard, C Stewart, NC Ngene, O Lunda, S N.Cebekhulu, S Moodley, MA Koranteng-Peprah, EMC Ati, S Maswime, LM Yates
Objective: To describe risk factors and outcomes of pregnant women infected with SARS-CoV-2 admitted to South African healthcare facilities. Methods: A population-based cohort study was conducted utilizing an amended International Obstetric Surveillance System protocol. Data on pregnant women with SARS-CoV-2 infection, hospitalized between April 14, 2020, and November 24, 2020, were analyzed. Results: A total of 36 hospitals submitted data on 673 infected hospitalized pregnant women; 217 (32.2%) were admitted for COVID-19 illness and 456 for other indications. There were 39 deaths with a case fatality rate of 6.3%: 32 (14.7%) deaths occurred in women admitted for COVID-19 illness compared to 7 (1.8%) in women admitted for other indications. Of the women, 106 (15.9%) required critical care. Maternal tuberculosis, but not HIV co-infection or other co-morbidities, was associated with admission for COVID-19 illness. Rates of cesarean delivery did not differ significantly between women admitted for COVID-19 and those admitted for other indications. There were 179 (35.4%) preterm births, 25 (4.7%) stillbirths, 12 (2.3%) neonatal deaths, and 162 (30.8%) neonatal admissions. Neonatal outcomes did not differ significantly from those of infected women admitted for other indications. Conclusion: The maternal mortality rate was high among women admitted with SARS-CoV-2 infection and higher in women admitted primarily for COVID-19 illness with tuberculosis being the only co-morbidity associated with admission.



International Journal of Gynecology and Obstetrics






United States