owens-maternalinsulin-2006.pdf (901.24 kB)
Maternal insulin-like growth factors-I and -II act via different pathways to promote fetal growth
journal contribution
posted on 2006-07-01, 00:00 authored by Amanda N Sferruzzi-Perri, Julie OwensJulie Owens, Kirsty G Pringle, Jeffrey S Robinson, Claire T RobertsThe placenta transports substrates and wastes between the maternal and fetal circulations. In mice, placental IGF-II is essential for normal placental development and function but, in other mammalian species, maternal circulating IGF-II is substantial and may contribute. Maternal circulating IGFs increase in early pregnancy, and early treatment of guinea pigs with either IGF-I or IGF-II increases placental and fetal weights by mid-gestation. We now show that these effects persist to enhance placental development and fetal growth and survival near term. Pregnant guinea pigs were infused with IGF-I, IGF-II (both 1 mg/kg.d), or vehicle sc from d 20-38 of pregnancy and killed on d 62 (term = 69 d). IGF-II, but not IGF-I, increased the mid-sagittal area and volume of placenta devoted to exchange by approximately 30%, the total volume of trophoblast and maternal blood spaces within the placental exchange region (+29% and +46%, respectively), and the total surface area of placenta for exchange by 39%. Both IGFs reduced resorptions, and IGF-II increased the number of viable fetuses by 26%. Both IGFs increased fetal weight by 11-17% and fetal circulating amino acid concentrations. IGF-I, but not IGF-II, reduced maternal adipose depot weights by approximately 30%. In conclusion, increased maternal IGF-II abundance in early pregnancy promotes fetal growth and viability near term by increasing placental structural and functional capacity, whereas IGF-I appears to divert nutrients from the mother to the conceptus. This suggests major and complementary roles in placental and fetal growth for increased circulating IGFs in early to mid-pregnancy.
History
Journal
EndocrinologyVolume
147Issue
7Pagination
3344 - 3355Publisher
Oxford University PressLocation
Oxford, Eng.Publisher DOI
ISSN
0013-7227Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2006, The Endocrine SocietyUsage metrics
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No categories selectedKeywords
AnimalsFemaleFetal DevelopmentGuinea PigsInsulin-Like Growth Factor Binding ProteinsInsulin-Like Growth Factor IInsulin-Like Growth Factor IIMaleMaternal-Fetal ExchangeMiceMothersPlacentaPregnancyPregnancy OutcomePregnancy, AnimalTrophoblastsScience & TechnologyLife Sciences & BiomedicineEndocrinology & MetabolismFOR-GESTATIONAL-AGEAMINO-ACID-UPTAKEADULT GUINEA-PIGIGF-IIFOOD RESTRICTIONHUMAN PLACENTAFEED RESTRICTIONBINDING-PROTEINSPHYSIOLOGICAL TRANSFORMATIONEXTRAVILLOUS TROPHOBLAST
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