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Maternal nutrition affects the ability of treatment with IGF-I and IGF-II to increase growth of the placenta and fetus, in guinea pigs

journal contribution
posted on 2001-12-01, 00:00 authored by A Sohlström, P Fernberg, Julie OwensJulie Owens, P C Owens
The aim of this study was to investigate how administration of IGF-I and IGF-II, during early to mid pregnancy, affects maternal growth and body composition as well as fetal and placental growth, in ad libitum fed, and in moderately, chronically food restricted guinea pigs. From day 20 of gestation, mothers (3-4 months old) were infused with IGF-I, IGF-II (565 microg/day) or vehicle for 17 days and then killed on day 40 of gestation. Maternal organ weights, fetal and placental weights were assessed. Treatment with IGFs did not alter body weight gain and had small effects on body composition in the mothers. Both IGF-I and IGF-II increased fetal and placental weights in ad libitum fed dams and IGF-I increased placental weight in food restricted dams. In conclusion, treatment with IGF-I during the first half of pregnancy stimulates placental growth in both ad libitum fed and food restricted guinea pigs without affecting maternal growth while fetal growth is stimulated by IGF treatment only in ad libitum fed animals.

History

Journal

Growth hormone & IGF research

Volume

11

Issue

6

Pagination

392 - 398

Publisher

Elsevier

Location

Amsterdam, The Netherlands

ISSN

1096-6374

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2001, Elsevier Science Ltd