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Mechanisms and efficacy of dietary FODMAP restriction in IBS

Version 2 2024-06-05, 08:34
Version 1 2019-01-31, 15:18
journal contribution
posted on 2024-06-05, 08:34 authored by Heidi StaudacherHeidi Staudacher, Peter M Irving, Miranda CE Lomer, Kevin Whelan
IBS is a debilitating condition that markedly affects quality of life. The chronic nature, high prevalence and associated comorbidities contribute to the considerable economic burden of IBS. The pathophysiology of IBS is not completely understood and evidence to guide management is variable. Interest in dietary intervention continues to grow rapidly. Ileostomy and MRI studies have demonstrated that some fermentable carbohydrates increase ileal luminal water content and breath hydrogen testing studies have demonstrated that some carbohydrates also increase colonic hydrogen production. The effects of fermentable carbohydrates on gastrointestinal symptoms have also been well described in blinded, controlled trials. Dietary restriction of fermentable carbohydrates (popularly termed the 'low FODMAP diet') has received considerable attention. An emerging body of research now demonstrates the efficacy of fermentable carbohydrate restriction in IBS; however, limitations still exist with this approach owing to a limited number of randomized trials, in part due to the fundamental difficulty of placebo control in dietary trials. Evidence also indicates that the diet can influence the gut microbiota and nutrient intake. Fermentable carbohydrate restriction in people with IBS is promising, but the effects on gastrointestinal health require further investigation.

History

Journal

Nature reviews: gastroenterology and hepatology

Volume

11

Pagination

256-266

Location

London, Eng.

ISSN

1759-5045

eISSN

1759-5053

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2014, Macmillan Publishers Limited

Issue

4

Publisher

Nature Publishing Group

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