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Mediterranean Style Dietary Pattern with High Intensity Interval Training in Men with Prostate Cancer Treated with Androgen Deprivation Therapy: A Pilot Randomised Control Trial
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posted on 2022-01-01, 00:00 authored by Brenton BaguleyBrenton Baguley, Kirsten Adlard, David Jenkins, Olivia R L Wright, Tina L SkinnerBackground: Androgen deprivation therapy (ADT) in prostate cancer has been shown to deteriorate body composition (reduced lean mass and increased body and fat mass) and increase the risk of cardiovascular morbidity. The Mediterranean style dietary pattern (MED-diet) and high intensity interval training (HIIT) may synergistically alleviate these side effects and improve quality of life in men treated with ADT. Methods: Twenty-three men (65.9 ± 7.8 years; body mass index: 29.6 ± 2.7 kg/m2; ADT duration: 33.8 ± 35.6 months) receiving ADT for ≥3 months were randomly assigned (1:1) to 20 weeks of usual care or the MED-diet (10 nutrition consults) with HIIT (4 × 4 min 85–95% heart rate peak, 3× week, starting at 12 weeks). Results: The MED-diet with HIIT significantly improved cardiorespiratory fitness (+4.9 mL·kg−1·min, p < 0.001), and body mass (−3.3 kg, p < 0.001) compared to the usual care group at 20 weeks. Clinically meaningful (≥3 points) improvements were seen in quality of life and cancer-related fatigue after 20 weeks. Conclusions: The MED-diet with HIIT increased cardiorespiratory fitness and reduced body weight in men with prostate cancer treated with ADT. Larger trials determining whether the MED-diet with HIIT translates to cardiovascular benefits are warranted
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Journal
International Journal of Environmental Research and Public HealthVolume
19Issue
9Article number
5709Pagination
1 - 17Publisher
MDPI AGLocation
Basel, SwitzerlandPublisher DOI
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1660-4601Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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Science & TechnologyLife Sciences & BiomedicineEnvironmental SciencesPublic, Environmental & Occupational HealthEnvironmental Sciences & Ecologymediterranean diethigh intensity interval trainingprostate cancerandrogen deprivation therapyQUALITY-OF-LIFEBODY-COMPOSITIONCARDIORESPIRATORY FITNESSFUNCTIONAL ASSESSMENTEXERCISEFATIGUEHEALTHINTERVENTIONSSURVIVALANEMIA
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