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Metabolic profiling of a transgenic Caenorhabditis elegans Alzheimer model

journal contribution
posted on 2023-11-10, 04:28 authored by R Van Assche, L Temmerman, DA Dias, B Boughton, K Boonen, BP Braeckman, L Schoofs, U Roessner
Despite decades of research, no early-onset biomarkers are currently available for Alzheimer’s disease, a cureless neurodegenerative disease afflicting millions worldwide. In this study, transgenic Caenorhabditis elegans were used to investigate changes in the metabolome after induced expression of amyloid-β. GC- and LC–MS-based platforms determined a total of 157 differential features. Some of these were identified using in-house (GC–MS) or public libraries (LC–MS), revealing changes in allantoin, cystathionine and tyrosine levels. Since C. elegans is far better suited to metabolomics studies than most other model systems, the accordance of these findings with vertebrate literature is promising and argues for further use of C. elegans as a model of human pathology in the study of AD.

History

Journal

Metabolomics

Volume

11

Pagination

477-486

Location

United States

ISSN

1573-3882

eISSN

1573-3890

Language

en

Publication classification

C1.1 Refereed article in a scholarly journal

Issue

2

Publisher

Springer Science and Business Media LLC