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Metabolic syndrome in polycystic ovary syndrome: a systematic review, meta-analysis and meta-regression

Version 2 2024-06-06, 10:51
Version 1 2018-11-27, 10:31
journal contribution
posted on 2024-06-06, 10:51 authored by SS Lim, NS Kakoly, JWJ Tan, G Fitzgerald, M Bahri Khomami, AE Joham, SD Cooray, ML Misso, RJ Norman, CL Harrison, S Ranasinha, HJ Teede, LJ Moran
INTRODUCTION: Women with polycystic ovary syndrome (PCOS) have increased risk of metabolic syndrome. The relative contribution of clinical, demographic or biochemical factors to metabolic syndrome in PCOS is not known. A literature search was conducted in MEDLINE, CINAHL, EMBASE and clinical trial registries. Of 4530 studies reviewed, 59 were included in the systematic review and 27 in the meta-analysis and meta-regression. In good and fair quality studies, women with PCOS had an overall increased prevalence of metabolic syndrome (odds ratio, OR 3.35, 95% confidence interval, CI 2.44, 4.59). Increased prevalence of metabolic syndrome occurred in overweight or obese women with PCOS (OR 1.88, 95% 1.16, 3.04) but not in lean women (OR 1.45, 95% CI 0.35, 6.12). In meta-regression analyses, the markers of metabolic syndrome diagnostic criteria (waist circumference, high-density lipoprotein cholesterol, triglyceride, blood pressure), BMI, glucose tolerance (2-hr oral glucose tolerance test) and surrogate markers of insulin resistance (HOMA-IR) but not markers of reproductive dysfunction (sex hormone binding globulin, testosterone, PCOS phenotypes) contributed significantly to the heterogeneity in the prevalence of metabolic syndrome. Women with PCOS have increased risk of metabolic syndrome which was associated with obesity and metabolic features but not with indices of hyperandrogenism.

History

Journal

Obesity reviews

Volume

20

Pagination

339-352

Location

Chichester, Eng.

eISSN

1467-789X

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2018, World Obesity Federation

Issue

2

Publisher

John Wiley & Sons

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