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Metabotropic glutamate receptors as targets for novel antipsychotic treatments.
journal contribution
posted on 2023-02-08, 03:43 authored by Laura GrayLaura Gray, AJ Hannan, X ZhangIn recent years metabotropic glutamate receptors have emerged as key targets for the design of new antipsychotic medications for schizophrenia, in particular mGluR5 and mGluR2/3. These receptors exhibit diverse interactions with other neurotransmitter receptors and critical elements of intracellular signalling cascades known to be important to the pharmacotherapy of schizophrenia. In addition, mGluR5 and mGluR2/3 are intimately involved in behavioural domains related to the symptoms of this disorder. Both animal and clinical studies using novel drugs targeting these receptors have provided encouraging results. The number of patents registered for drugs targeting metabotropic glutamate receptors has grown dramatically, and positive allosteric modulators for both receptors show particular promise.
History
Journal
Current pharmaceutical biotechnologyVolume
13Pagination
1522-1534Location
Amsterdam, The NetherlandsPublisher DOI
ISSN
1873-4316eISSN
1873-4316Language
engPublication classification
C Journal article, C1.1 Refereed article in a scholarly journalCopyright notice
2012, Bentham Science PublishersIssue
8Publisher
Bentham Science PublishersUsage metrics
Categories
Keywords
AnimalsAntipsychotic AgentsHumansReceptors, Metabotropic GlutamateSchizophreniaScience & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyPharmacology & PharmacyAntipsychoticMetabotropic Glutamate receptorsmGluR5mGluR2mGluR3POSITIVE ALLOSTERIC MODULATORLONG-TERM POTENTIATIONADENOSINE A(2A) RECEPTORSPROTEIN-KINASE-CDORSOLATERAL PREFRONTAL CORTEXPREPULSE INHIBITION DEFICITCENTRAL-NERVOUS-SYSTEMRAT DORSAL STRIATUMGROUP-INMDA RECEPTORNeurosciencesBrain DisordersMental HealthSerious Mental Illness5 Development of treatments and therapeutic interventions5.1 PharmaceuticalsMental health111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified970111 Expanding Knowledge in the Medical and Health SciencesSchool of MedicinePharmacology and Pharmaceutical Sciences not elsewhere classifiedMedical Biotechnology not elsewhere classified
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