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MicroRNA pathways : an emerging role in identification of therapeutic strategies

Version 2 2024-06-06, 08:57
Version 1 2015-03-19, 11:37
journal contribution
posted on 2024-06-06, 08:57 authored by S Vijayarathna, CE Oon, SL Jothy, Y Chen, JR Kanwar, S Sasidharan
For years researchers have exerted every effort to improve the influential roles of microRNA (miRNA) in regulating genes that direct mammalian cell development and function. In spite of numerous advancements, many facets of miRNA generation remain unresolved due to the perplexing regulatory networks. The biogenesis of miRNA, eminently endures as a mystery as no universal pathway defines or explicates the variegation in the rise of miRNAs. Early evidence in biogenesis ignited specific steps of being omitted or replaced that eventuate in the individual miRNAs of different mechanisms. Understanding the basic foundation concerning how miRNAs are generated and function will help with diagnostic tools and therapeutic strategies. This review encompasses the canonical and the non-canonical pathways involved in miRNA biogenesis, while elucidating how miRNAs regulate genes at the nuclear level and also the mechanism that lies behind circulating miRNAs.

History

Journal

Current Gene Therapy

Volume

14

Pagination

112-120

Location

Bussum, Netherlands

ISSN

1875-5631

Language

eng

Publication classification

C Journal article, C1 Refereed article in a scholarly journal

Copyright notice

2014, Bentham Science Publishers

Issue

2

Publisher

Bentham Science Publishers